IRON METABOLISM DISORDERS AND THEIR PHARMACOLOGICAL CORRECTION

The main pathological conditions characterized by disturbances of iron metabolism have been analyzed, including anemias, hemochromatosis, inflammatory, autoimmune and neurodegenerative disorders, chronic renal insufficiency, infectious diseases (including COVID-19), etc. Strategies of their pharmacological correction and risks of common adverse effects development are considered for the potential targets of pharmacotherapy and possible groups of medications including inhibitors of prolyl-4-hydroxylase, inhibitors of bone morphogenetic proteins (BMP 6), ferroportin and hepcidin activity, inhibitors of hypoxia-inducible factor (HIF-1a) and divalent metal transporter (DMT-1). Copyright © 2022 Izdatel'stvo Meditsina. All rights reserved.